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Hello there, 

You’ve heard of blackberries, but have you ever heard of Boysenberries?

Boysenberries are the delicious hybrid between raspberries, blackberries, and loganberries. Packed with vitamins, minerals, and powerful polyphenols, these dark berries are now gaining attention for their role in promoting vascular and angiogenic health. Emerging research suggests that the polyphenols in boysenberries may help keep blood vessels flexible, reduce oxidative stress, and support healthy angiogenesis—the process that maintains balanced blood vessel growth, which is essential for cardiovascular health.

What Exactly are Boysenberry Polyphenols?

Polyphenols are natural plant compounds with antioxidant and anti-inflammatory properties. Boysenberries are particularly rich in anthocyanins, the pigments responsible for their deep purple color, along with ellagitannins and proanthocyanidins. These compounds not only give the berries their vibrant hue but also interact with endothelial cells—the inner lining of our blood vessels—to protect them from stress and aging.

Among boysenberry polyphenols, anthocyanins such as cyanidin-3-glucoside play a starring role. They help neutralize reactive oxygen species (ROS) and support nitric oxide (NO) production, which are two critical factors for healthy vascular tone and angiogenesis.

What the Research Shows

A 2018 study published in PLOS ONE (Furuuchi et al.) revealed that boysenberry polyphenol (BP) can significantly improve vascular function under metabolic stress. In mouse models of obesity, BP supplementation:

• Reduced oxidative stress (ROS) in blood vessels

• Lowered p53 expression, a marker of endothelial cell senescence (cell cycle arrest, linked to aging)

• Increased nitric oxide (NO) availability improves vessel relaxation and blood flow

• Promoted eNOS dimerization, a molecular step crucial for NO synthesis and balanced angiogenesis

Further studies using human endothelial cells confirmed these effects. When exposed to palmitic acid (a stressor that mimics metabolic dysfunction), cells treated with boysenberry polyphenols showed:

• Decreased oxidative damage

• Higher NO production

• Reduced cellular aging

Importantly, anthocyanins isolated from boysenberry polyphenols were identified as the main active components. In both in vitro and ex vivo experiments, they protected endothelial cells, improved vessel dilation, and suppressed inflammatory signaling—all contributing to healthier vascular and angiogenic balance.

Want to learn more about boysenberries and how to add them to your diet?

Download our free Bioactive Spotlight guide featuring the bioactive—plus simple tips to help you safely add these compounds to your meals.

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Best wishes,
- The Angiogenesis Foundation

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