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Can Polyphenols Help Grow Healthy Blood Vessels?

A review published in 2023 in Nutrients highlights a fascinating connection between certain plant compounds—called polyphenols—and the health of our blood vessels. Polyphenols are natural bioactive substances found in colorful fruits, vegetables, tea, coffee, red wine, herbs, and spices. While not considered essential nutrients like vitamins or minerals, they may play a powerful role in supporting overall health.

One of their lesser-known benefits? Supporting the body’s ability to grow new blood vessels—a process called beneficial angiogenesis. This process is essential for circulation, wound healing, and recovery from injury.

According to the review, polyphenols act as multitaskers. They interact with the body’s signaling systems and may help activate growth pathways—like VEGF—that are involved in creating new vessels. Researchers suggest this effect is dose-dependent and context-specific, meaning polyphenols may help stimulate angiogenesis when and where it’s needed most, such as in areas of poor circulation or tissue damage.

What the Study Found

Here’s what the researchers focused on:

• Certain polyphenols may activate vessel-building signals.
  Compounds like resveratrol (in red grapes), EGCG (in green tea), and curcumin (in turmeric) may help activate VEGF, a key protein that stimulates the growth of new blood vessels.

• They help reduce inflammation and oxidative stress linked to vessel damage.
  Polyphenols may lower activity in pathways like NF-κB and reduce reactive oxygen species—both of which are associated with vascular injury. By protecting existing vessels, they may help create conditions that support healthy vessel growth.

• Effects depend on timing, dose, and body needs.
  The review emphasizes that polyphenols don’t push blood vessel growth randomly—they work with the body’s natural healing cues and may be especially helpful after injury or during recovery.

Why This Matters

This research highlights how food can be more than fuel—it can play a role in maintaining and repairing your body’s circulation.

Supporting healthy angiogenesis may help:

• Restore blood flow in areas with poor circulation

• Support recovery after injury or illness

• Promote brain and heart health over time

• Protect against vascular aging

And the best part? You don’t need drastic changes to get started. Simply including a variety of polyphenol-rich foods—like berries, green tea, olive oil, turmeric, chocolate, and leafy greens—can help support healthy blood vessels.

After all, whole foods deliver a diverse mix of nutrients and natural compounds that work together to protect your circulation, support tissue repair, and promote overall health.

Want a practical place to start?

Download our free guide featuring three simple exercises that get your blood flowing—and may help support healthy circulation from the inside out.

Stay connected with us to receive the latest on evidence-based research, advancements in healthcare, and practical tips.

Best wishes,
- The Angiogenesis Foundation

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